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Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 225-228 doi: 10.1007/s11684-010-0003-z
Keywords: bradykinin vascular smooth muscle cells signal transduction pathways
CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,
Keywords: electrical signal / glutamate receptor-like / herbivory / jasmonic acid / tomato
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
Yuan CHEN, Qi TIAN
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 70-76 doi: 10.1007/s11684-011-0119-9
Keywords: signal transduction neurogenic disease
Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 363-367 doi: 10.1007/s11684-009-0064-z
Keywords: liver disease alcohol Zhihuang decoction CD14 signal transduction
Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tail in integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model. Chimeric Tac-β3 proteins (i.e., Tac-β3, Tac-β3D741, Tac-β3D747, Tac-β3D754, Tac-β3D759, and Tac-β3DNITY) consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmic domain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrin αIIbβ3. The different cells were assayed for stable adhesion and spreading on immobilized fibrinogen, and for binding soluble fibrinogen representing outside-in and inside-out signaling events, respectively. The chimeric protein Tac-β3 inhibited, and Tac-β3DNITY partially attenuated stable adhesion and spreading. Tac-β3, Tac-β3D759, Tac-β3DNITY, and Tac-β3D754, but not Tac-β3D747 or Tac-β3D741, impaired the soluble fibrinogen binding. Results indicated that the bidirectional signaling was significantly inhibited by Tac-β3 and Tac-β3DNITY, albeit to a much lesser extent. Moreover, only inside-out signaling was impaired in the 123/Tac-β3D759 and 123/Tac-β3D754 cells in contrast to an intact bidirectional signaling in the 123/Tac-β3D747 and 123/Tac-β3D741 cells. In conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic proteins rather than altering its conformation, and may thus regulate platelet function.
Keywords: integrin β3 signal transduction trans-dominant inhibition model
Li LI, Jianxin JIANG
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 33-39 doi: 10.1007/s11684-011-0114-1
Keywords: mesenchymal stem cells migration molecular mechanisms signaling pathway
Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 6-16 doi: 10.1007/s11684-014-0317-3
Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.
Keywords: signal transduction transmembrane domain nanodisc integrin talin kindling cell adhesion
Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,
Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 431-436 doi: 10.1007/s11684-009-0088-4
Keywords: tanshinone II A myocardial hypertrophy rat protein kinase B abdominal aorta coarctation
GONG Yanwen, REN Defeng, YUAN Yingjin
Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 2, Pages 118-122 doi: 10.1007/s11705-007-0022-8
Keywords: transduction chinensis feedback environmental generation
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 46-53 doi: 10.1007/s11684-010-0010-0
Keywords: mitogen-activated protein kinase drug target inhibitor signal transduction disease
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 12, Pages 1700-1712 doi: 10.1007/s11705-022-2207-6
Keywords: naphtha catalytic pyrolysis reaction pathway equilibrium yield
Seasonal variations of transport pathways andpotential sources of PM
Yuan Chen, Shaodong Xie, Bin Luo
Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 1, doi: 10.1007/s11783-018-1009-z
Keywords: Transport pathway Backwardtrajectory Clustering analysis Potential source Chengdu
ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE
Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3, Pages 316-332 doi: 10.15302/J-FASE-2022441
● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.
Keywords: Nitrogen root system architecture phytohormone crosstalk nitrogen-use efficiency breeding strategy
Frontiers of Environmental Science & Engineering doi: 10.1007/s11783-021-1481-8
Keywords: Acidogenic phase reactor High-sulfate wastewater Sulfate reduction Acidogenic fermentation PICRUSt2
Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer
Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,
Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 247-253 doi: 10.1007/s11684-010-0027-4
Keywords: gastric carcinoma metastasis signal transduction gene chips
Title Author Date Type Operation
of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved signaltransduction pathways
Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,
Journal Article
CHARACTERISTICS OF HERBIVORY/WOUND-ELICITED ELECTRICAL SIGNAL TRANSDUCTION IN TOMATO
Journal Article
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
Yuan CHEN, Qi TIAN
Journal Article
Effect of decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced
Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,
Journal Article
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Journal Article
Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction
Li LI, Jianxin JIANG
Journal Article
Talin and kindlin: the one-two punch in integrin activation
Feng Ye, Adam K. Snider, Mark H. Ginsberg
Journal Article
Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial
Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,
Journal Article
Neural networks modeling signal responses and taxol production of cultured Taxus chinensis cells induced
GONG Yanwen, REN Defeng, YUAN Yingjin
Journal Article
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
Journal Article
Thermodynamic analysis of reaction pathways and equilibrium yields for catalytic pyrolysis of naphtha
Journal Article
Seasonal variations of transport pathways andpotential sources of PM
Yuan Chen, Shaodong Xie, Bin Luo
Journal Article
ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE
Journal Article
PICRUSt2 functionally predicts organic compounds degradation and sulfate reduction pathways in an acidogenic
Journal Article